Treatment of Acute Proximal Interphalangeal Joint Palmar Plate Injury by Bone Channel Suture

Objective: Objective: To explore the surgical efect of suture through bone canal in the treatment of reconstruction of acute prox-imal interphalangeal joint metacarpal anchorage. Methods From July 2018 to August 2021, we retrospectively analyzed 9 cases of avulsion of metacarpal plate near interphalangeal joint, including 7 males and 2 females, aged 17-40 years, with an average of 34 years. There were 4 cases of index fnger, 3 cases of middle fnger and 2 cases of ring fnger. Early fexion and extension exercises were performed after opera-tion. The last follow-up included the range of motion of the proximal interphalangeal joint and joint pain. Results All patients were followed up (4-12 months) after operation.According to the TAM method, 7 cases were excellent and 2 cases were good. Conclusion Transosseous su-ture for acute proximal interphalangeal joint metacarpal reconstruction has the advantages of simple operation, safety, frm fxation and rapid postoperative recovery

Experimentally well-constrained masses of 27P and 27S: implications for studies of explosive binary systems

The mass of 27P is expected to impact the X-ray burst (XRB) model predictions of burst light curves and the composition of the burst ashes, but large uncertainties and inconsistencies still exist in the reported 27P masses. We have used the ß-decay spectroscopy of 27S to determine the most precise mass excess of 27P to date to be keV, which is 63 keV (2.3s) higher and a factor of 3 more precise than the value recommended in the 2016 Atomic Mass Evaluation. Based on the new 27P mass, the P reaction rate and its uncertainty were recalculated using Monte Carlo techniques. We also estimated the previously unknown mass excess of 27S to be 17678(77) keV, based on the measured ß-delayed two-proton energy and the Coulomb displacement energy relations. The impact of these well-constrained masses and reaction rates on the modeling of the explosive astrophysical scenarios has been investigated by post-processing XRB and hydrodynamic nova models. Compared to the model calculations based on the masses and rates from databases, the abundance of in the burst ashes is increased by a factor of 2.4, while no substantial change was found in the XRB energy generation rate or the light curve. Our calculation also suggests that 27S is not a significant waiting point in the rapid proton capture process, and the change of the P reaction rate is not sufficiently large to affect the conclusion previously drawn on the nova contribution to the synthesis of galactic 26Al.Postprint (published version

Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci

It has been shown that, during the S-phase of the cell cycle, the mouse DNA methyltransferase (DNA MTase) is targeted to sites of DNA replication by an amino acid sequence (aa 207-455) lying in the N-terminal domain of the enzyme [Leonhardt, H., Page, A. W., Weier, H. U. and Bestor, T. H. (1992) Cell, 71, 865-873]. In this paper it is shown, by using enhanced green fluorescent protein (EGFP) fusions, that other peptide sequences of DNA MTase are also involved in this targeting. The work focuses on a sequence, downstream of the reported targeting sequence (TS), which is homologous to the Polybromo-1 protein. This motif (designated as PBHD) is separated from the reported targeting sequence by a zinc-binding motif [Bestor, T. H. (1992) EMBO J, 11, 2611-2617]. Primed in situ extension using centromeric-specific primers was used to show that both the host DNA MTase and EGFP fusion proteins containing the targeting sequences were localized to centromeric, but not telomeric, regions during late S-phase and mitosis. Also found was that, in ∼10% of the S-phase cells, the EGFP fusions did not co-localize with the centromeric regions. Mutants containing either, or both, of these targeting sequences could act as dominant negative mutants against the host DNA MTase. EGFP fusion proteins, containing the reported TS (aa 207-455), were targeted to centromeric regions throughout the mitotic stage which lead to the discovery of a similar behavior of the endogenous DNA MTase although the host MTase showed much less intense staining than in S-phase cells. The biological role of the centromeric localization of DNA MTase during mitosis is currently unknow

SEAT: Stable and Explainable Attention

Currently, attention mechanism becomes a standard fixture in most state-of-the-art natural language processing (NLP) models, not only due to outstanding performance it could gain, but also due to plausible innate explanation for the behaviors of neural architectures it provides, which is notoriously difficult to analyze. However, recent studies show that attention is unstable against randomness and perturbations during training or testing, such as random seeds and slight perturbation of embedding vectors, which impedes it from becoming a faithful explanation tool. Thus, a natural question is whether we can find some substitute of the current attention which is more stable and could keep the most important characteristics on explanation and prediction of attention. In this paper, to resolve the problem, we provide a first rigorous definition of such alternate namely SEAT (Stable and Explainable Attention). Specifically, a SEAT should has the following three properties: (1) Its prediction distribution is enforced to be close to the distribution based on the vanilla attention; (2) Its top-k indices have large overlaps with those of the vanilla attention; (3) It is robust w.r.t perturbations, i.e., any slight perturbation on SEAT will not change the prediction distribution too much, which implicitly indicates that it is stable to randomness and perturbations. Finally, through intensive experiments on various datasets, we compare our SEAT with other baseline methods using RNN, BiLSTM and BERT architectures via six different evaluation metrics for model interpretation, stability and accuracy. Results show that SEAT is more stable against different perturbations and randomness while also keeps the explainability of attention, which indicates it is a more faithful explanation. Moreover, compared with vanilla attention, there is almost no utility (accuracy) degradation for SEAT.Comment: To be appeared in AAAI 202

Existence and Exponential Stability of Equilibrium Point for Fuzzy BAM Neural Networks with Infinitely Distributed Delays and Impulses on Time Scales

By using the fixed point theorem and constructing a Lyapunov functional, we establish some sufficient conditions on the existence, uniqueness, and exponential stability of equilibrium point for a class of fuzzy BAM neural networks with infinitely distributed delays and impulses on time scales. We also present a numerical example to show the feasibility of obtained results. Our example also shows that the described time and continuous neural time networks have the same dynamic behaviours for the stability